International Conference on Organic Chemistry August 10-11, 2016 Las Vegas, Nevada, USA

A A Prishchenko has completed his PhD from M V Lomonosov Moscow State University at the Department of Chemistry and now he is a Leading Researcher in the same university. He has published more than 200 papers in reputed journals on Organophosphorus Chemistry.

The functionalized organophosphorus derivatives of aminocarboxylic acids and their corresponding peptides are the perspective organophosphorus biomimetics of natural phosphates and hydroxy or amino acids. These compounds with nonhydrolysable P-C bonds interfere with various enzymatic processes and possess the antibacterial, antiviral, antibiotic, pesticidal, antitumor and enzyme inhibitory properties. Several organophosphorus containing peptides with proline moieties have attached attention in the capacity of the competitive inhibitors of human immunodeficiency virus protease. Recently the organophosphorus derivatives of glycine, β-alanine and γ-aminobutyric acid with PCH2N moieties have been synthesized by us. We have developed a convenient two- or three-component aminomethylation of various PH-acids as the perspective method for synthesis of mono- and bisorganophosphorus proline derivatives with P-C-N moieties using proline or its highly reactive functionalized precursors. Trimethylsilyl-containing organophosphorus compounds easily react with methanol excess or with sodium methylate in methanol giving water soluble acids or their sodium salts in high yelds.rnrnSo the unique synthesis of proline-containing organophosphorus acids and their derivatives with 3-,4- и 5-coordinated phosphorus starting from available reagents were developed by us. The resulting compounds are the promising synthons for preparation of various organophosphorus peptides with different arrangement of proline moieties as well as the perspective polydentate ligands and biologically active substances with versatile properties.rn

A A Prishchenko has completed his PhD from M V Lomonosov Moscow State University at the Department of Chemistry. Now he is the Leading Researcher of M V Lomonosov Moscow State University at the Department of Chemistry. He has published more than 200 papers in reputed journals on Organophosphorus Chemistry.

Functionalized organophosphorus acids and their derivatives with heterocyclic moieties are of great interest as effective chelating ligands and perspective bioactive substances with various properties. These acids are well-known biomimetics of hydroxyl (amino) carbonic acids and natural pyrophosphates, and some of them such as zoledronic, risedronic, and minodronic acids are widely used in medicine. We have synthesized the new functionalized mono- and diphosphonic acids and their derivatives including five-membered nitrogen heterocycles via two- or three-component aminomethylation of several trimethylsilyl esters of phosphorous acid using as starting compounds recently available NH-heterocycles and triethyl orthoformate.Trimethylsilyl-containing organophosphorus compounds easily react with methanol excess or with sodium methylate in methanol giving water soluble acids or their sodium salts in high yields. The resulting compounds are the perspective polydentate ligands and biologically active substances with versatile properties as well as the promising precursors for multitarget drug discovery.

F N Naghiyev has completed his PhD from Baku State University, Azerbaijan. Currently, he is a Post-doctoral Researcher and Specialist in the NMR laboratory at the same university. He has published more than 14 papers, also one patent in local and international literature.

Many pyran derivatives exhibit a wide spectrum of pharmacological activities and biological activities at melanocortin receptors and are being used in the design of peptidomimetics relating to a tripeptide structure, such as fungicidal, insecticidal and acaricidal activity, antiviral activity, miticidal activity, stimulant activity and anti¬con¬vul¬sant activity. Because of the toxic and volatile nature of many organic solvents, ionic liquids and aqueous media are emerging as effective solvents for ‘green’ processes. Water is cheap, not dangerous and very digressive for environment, so it is used as solvent in Diels-Alder’s, Klayzen rearrangement, Reformatski and pinakol-interaction reactions. Due to this reason, China scientist Xiang-Shan Wang used aceto-acetic with arylmethylidene-malonnitriles in water solution and in the presence of catalyst triethyl¬benzyl¬am¬monium chloride (TEBAX) obtained 6-amino-5-ciano-4-aryl-2-methyl-4H-pyran-3-carboxylate deriva¬ti¬ves with high yield. Egyptian scientists F M Abdelrazek and others presented the same reaction with ammonia acetate in ethanol media and they obtained pyran which was subjected to substitution reaction and its pro¬ducts were reacted in the presence of TEA and ethanol with thiocarbamide and got pirimidine derivatives which contained pyran ring. When we carried out the alkylation of benzylidene malononitrile and acetoacetanilide in the ethanol media, in the presence of piperidine (piperazine), formation of product 1 was observed the. During NMR studies of the compound 1 in DMSO-d6 has been identified the keto-enol tautomerism. When we used sodium methylate as base, the different product 2 was obtained. From all these observation, we propose that, in this case also the formation of product 1 took place, but then it underwent the attack of methoxide anion which resulted in the splitting of methyl acetate to give product We established that in benzene media in the presence of piperidine by interaction of benzilidene malononitrile with benzoylacetone product 3 were obtained. We propose that in these conditions the enolization of benzoylacetone can take place in carbonyl group near the methyl group. When we changed the reaction condition, which means using piperazine as base and methanol as solvent, the formation of product 4 took place. Probably in the second case, the enolization took place in carbonyl group near the phenyl group.

Simurova N V is an Associate Professor in Organic Chemistry department, National University of Food Technologies of Ukraine. She has previously worked as a Synthetic Organic Chemist at the Institute of Organic Chemistry of the National Academy of Sciences of Ukraine. She is the author of over 50 scientific publications and textbooks on organic synthesis of medicines.

Indolo[2,3-b]quinoxalines is formed when indole and quinoxaline fragments combine to form an heterocycle. These heterocyclic systems are interesting for research due to the properties like antiviral, antitoxic activity, as well as powerful intercalators exhibiting cytotoxic and interferon-inducing activity. State of art literature data analysis shows that, acyl or alkyl substituents at the nitrogen atom of the indole fragment is necessary for the manifestation of biological activity. Methods of synthesizing such compounds are complex and not numerous, so the search for new methods is still relevant. We have studied the reaction of alkylisatins and benzoylisatin with 4-methylbenzene-1,2-diamine, which in one stage results in the derivatives of 6H-indolo- [2,3-b] quinoxaline with a substituent at the nitrogen atom of the indole fragment. We have found that, the condensation of alkyl and benzoylisatins with 4-methylbenzene-1,2-diamine in glacial acetic acid which proceeds stereo-selectively results in the formation of 3-methyl-6R-indolo [2,3-b] quinoxalines. Hence, by the methyl group oxidation previously unknown indolo [2,3-b] quinoxaline carbaldehydes have been received, and by the nitro group reduction - the corresponding indoloquinoxaline amines were obtained.

Manabu Kuroboshi has completed his PhD from Kyoto University and worked in Sagami Chemical Research Center, Tokyo Institute of Technology, and Okayama University. He is now an Associate Professor in Okayama University. His main research interests are in Electroorganic Chemistry and Heteroatom Chemistry.

Ph3P is widely used in synthesis of natural products via Wittig reaction, Mitsunobu reaction, Mukaiyama-Corey lactonization, Appel reaction, Staudinger reaction, and so on. In these reactions, Ph3P is oxidized to afford Ph3P=O. From the view of atom economy strategy, recycle use of P compounds to use it repeatedly is a keen project. For this purpose, a combination of reductant (PV to PIII) and deoxygenizer should be developed. We chose Mg as a powerful and air-stable reductant, and Me3SiCl as a deoxygenizer. We examined the reduction under several reaction conditions, and found that the solvent is the most important factor for this reduction. This reduction only proceeded in DMI (1,3-dimethylimidazolidinone) to give Ph3P quantitatively (Entry 1): In other solvents such as MeCN, DMF, DMAc, NMP, DMPU, and THF, most of Ph3P=O was recovered intact (Entries 2-7). Several phosphine oxides were reduced under similar reaction conditions. Triarylphosphine oxides gave the corresponding triarylphosphine in quantitative yields (Entries 1–4), whereas triarylphosphine oxide having an electron-withdrawing group such as (4-cyanophenyl)diphenylphosphine oxide gave only a complex mixture (Entry 5). Alkyldiarylphosphine oxides (entries 6 and 7) and dialkylarylphosphine oxide (entry 8) were also reduced with the Mg/Me3SiCl/DMI system to afford the corresponding phosphine derivatives in good yields, whereas, trialkylphosphine oxide was not reduced at all (Entry 9). In this stage, we have no critical answer why the reduction occurs only in DMI, since DMI itself is not a unique solvent. However, (a combination of) solvent (and additive) sholud play an important role especially in Electron-Transfer Reaction.

Harapriya Rath has completed her PhD in 2006 from Indian Institute of Technology, Kanpur and JSPS Post-doctoral studies from Kyoto University, Japan followedrnby Royal Society Newton International Postdoctoral studies from Manchester University. She has been awarded the Ramanujan fellowship by Derpartmentrnof Science and Technology, India. She currently holds the position of Assistant Professor in the Department of Inorgaic Chemistry, Indian Association for thernCultivation of Science, Kolkata, India. Her major research area includes highly conjugated topologically controlled Aromaticity, molecular spintronics, NIR absorptivernand emissive dyes.

Aromaticity is one important single parameter that controls stability, structure, reactivity and material applicability ofrnvarious molecular species. In this respect, the conformational flexibility of expanded heteroannulenes and aromaticityrnin many cases become specular images of one another. Thus, there always remains challenge in designing or finding a suitablernpreorganized precursor (s) that can probe the serious exploratory problems owing to usually larger conformational mobilityrnwhile maintaining aromaticity for expanded porphyrins with full potential as efficient NIR dyes. The first part of my talk willrnhighlight the induced correspondence of local π-aromatic sextet onto the macrocyclic π-conjugation pathways leading torndifferent topologies with aromaticity switching. I would discuss the very first report of an unconventional tripyrrane moietyrnthat has been obtained from regioselective β-benzoyllated pyrrole. The unconventional 3, 4-linkages of N-methyl pyrrole unitrnhas admirably served as incentive to two different types of highly stable metal free [20] Möbius aromatic heteroannulenes. Mostrnimportantly, the presence of the “local” aromatic unit (N-methyl pyrrole considering 3, 4-linkages) in the macrocycle corerndidn’t necessarily quench the macrocyclic diatropic ring current effect (Chem. Asian. J. 2016, 11 (7), 986-990). On the otherrnhand, attempt to include local π-aromatic sextets viz the N-methyl pyrrole rings through β, β-linkages and α, β-linkages has ledrnto the isolation of first ever heteroannulenes cross conjugated at four points and two points respectively within the macrocyclesrnand hence the loss of aromaticity in these macrocycles (Chem. Eur. J. 2016, 22, 5504-5508). In the second part of my talk,rnthe induced correspondence of fused heterocycles in to the macrocyclic π-conjugation pathways leading to NIR absorptionrnand emission (Chem. Eur. J. 2016, chem.201600917). The impact of such topology switching has led to dynamic aromaticityrnswitching. Excellent agreement between the theoretically determined and experimentally spectroscopic measurement are keyrnto the evidence of such aromaticity switching.

Abdellatif El kihel is professor in Université Chouaib Doukkali, El Jadida.rnrnHis specilization is in the field of Organic Chemistry, Analytical Chemistry, Organometallic Chemistry

2-mercaptobenzimidazole derivatives were synthesized by reaction of o-phenylenediamines with N-aminorhodanine. This reaction represent a new synthesis of 2-mercaptobenzazoles. The structure of the obtained products was established by spectroscopic data.

Dr. Lakshmi C. Kasi Viswanath is currently working as an assistant professor at Oklahoma Baptist University. Her research focus lies on supramolecules, development of donor acceptor conjugates for organic solar cells and light harvesting systems. She has published many articles in international journals including a book chapter. She also serves as a reviewer for reputed journals and also a member of editorial board. She actively participates in ACS conferences.

Benzo[ghi]peryleneimides constitute a unique class of fluorescent perylene dyes which possesses great synthetic diversity due to the presence of a large number of reactive active sites (availbility of third imide region). Taking advantage of this additional active site we synthesized a new series of benzo[ghi]perylenetriimides comprised of alkyl- and aryl- substituents in the third imide region. The core extension of perylene diimides was performed using a Diels-Alder reaction to afford diimido anhydride which provided access to the various triimides with yields ranging from 58%–69%. The combined spectroscopic and electrochemical studies revealed strong electron accepting propeties of the triimides. Potential application of the synthesized triimides for various optoelectronic devices and as non-fullerene electron acceptors in photovoltaics is evident from this study.