Day 2 :
Keynote Forum
Xintao Wu
Chinese Academy of Sciences, China
Keynote: Investigations of transition metal complexes with fluorescence or metal to metal charge transfer properties
Time : 00:00-00:30
Biography:
Professor Xin-Tao Wu graduated from Xiamen University in 1960 and completed his Master Degree in Science from Fuzhou University in 1966. He is Professor of Chemistry, Director of the Academic Committee from 2000 to 2013, Fujian Institute of Research on the Structure of Matter, Chinese academy of Sciences, and has been a Member of the Chinese Academy of Sciences from 1999. He has published more than 300 papers in reputed international chemical journals.
Abstract:
Metal-organic framework materials with fluorescent, white light or gas-adsorption properties, and transition metal clusters with metal to metal charge transfer properties have become of much interest in fundamental research and modern material science. Recently, the following investigations have been made in my research group: (1) A series of neutral MOFs encapsulated various neutral and ionic guest dye molecules have been designed and synthesized, their luminescent properties have been investigated. The white light- emitting MOF materials could be designed and prepared when three red/green/ blue-emitting dyes were introduced simultaneously into such MOF host. Interestingly, the white light is tunable by changing the content or type of the three dye guests, or the excitation wavelength. (2) A series of new luminescent zinc or lanthanide phosphonates and their luminescent properties have been investigated. Furthermore, some lanthanide phosphonates exhibit the remarkable capability to rapidly detect trace amounts of nitroaromatic explosives through luminescent quenching. The sensitivity, fast response, facile synthesis, low usage, cheapness, and good stability make it one of the most powerful nitroaromatic explosives sensors known. (3) A series of mixed valent cyanidometal bridged compounds have been designed, synthesized and characterized, their metal to metal charge transfer properties and the influence factors of electron transfer process have been investigated. In particular, an unusually delocalized mixed-valence state of a cyanidometal bridged compound induced by thermal electron transfer have been reported for the first time.
Keynote Forum
Yuichi Shimazaki
College of Science Ibaraki University, Japan
Keynote: Oxidation chemistry of group 10 metals-di(phenolate) complexes 0(Ni, Pd and Pt) with Schiff base ligands
Time : 00:00-00:30
Biography:
Yuichi Shimazaki was born in 1970 in Toyama prefecture, Japan. He received his Doctor’s degree in science from Nagoya University in 2000 under the supervision of Professor Osamu Yamauchi. He joined Professor Yoshinori Naruta’s group at Kyushu University as Assistant Professor and worked on the redox behavior of various metal porphyrin complexes as models of the active site of metalloenzymes. In 2008 he was promoted to Associate Professor at the College of Science, Ibaraki University. His research interests include the oxidation chemistry of the complexes of various metal ions, model studies of metalloenzymes, bioorganometallic chemistry, and weak interactions in metal-organic molecule systems.
Abstract:
Oxidation chemistry of redox active transition metal complexes with pro-radical ligands and their detailed electronic structures have been actively pursued in recent years. Many efforts for determination of the experimental oxidation number have been close to the goal of the “truth oxidation state” in various oxidized metal complexes with non-innocent ligands. Depending on the relative energies of the redox-active orbitals, metal complexes with non-innocent ligands exist in two limiting descriptions, either a metal-ligand radical (Mn+(L·)) or a high valent metal (M(n+1)+(L-)) complex. In order to understand that factors affect the oxidation locus of the oxidized metal(II)-salen-type complexes, we have investigated isolation and X-ray crystal structure determination of the one–electron oxidized metal(II)–salen-type complexes, and characterization of their electronic structures by various spectroscopic methods. Oxidized NiII-salen complexes, which have a diphenolate ligand with square planar geometry, are known to exist in either form, and the factors that control the locus of oxidation in these complexes are being pursued currently. One-electron oxidation of Ni-salen-type complexes forms the NiII–phenoxyl radical species, while addition of exogeneous ligands to the NiII–phenoxyl radical solution gives the metal-centered oxidation, NiIII–phenolate species. On the other hand, Pd and Pt complexes show a different oxidation behavior and electronic structure. The one-electron oxidized Pt complex is preferable for the delocalization of the radical electron on the two phenolate moieties while the unpaired electron in the oxidized Pd complexes are more localized on the one-side of the phenolate moiety. In this presentation oxidation behavior of the Group 10 metal(II)-di(phenolate) complexes will be focused, especially detailed electronic structures of oxidized Group 10 metal(II)-di(phenolate) complexes.
Keynote Forum
Saad Alotaibi
Taif University, Kingdom of Saudi Arabia
Keynote: E-BABE: Synthesis of magnesium aluminate composites reinforced with ceramic particulates for grinding applications
Time : 00:00-00:30
Biography:
Saad Alotaibi has completed his PhD at the age of 28 years from Western Michigan University and postdoctoral studies from King Abdullah University School of Chemistry. He is the Dean of Turabah University College. He has published more than 8 papers in reputed journals and has been serving as an editorial board member of repute.
Abstract:
This project aimed at investigating the possibility to synthesize magnesium aluminate composite reinforced with ceramics particulates to be used as grinding materials. Generally, magnesium aluminate (MgAl2O4) is commonly used in the industries as refractories. Due to its high chemical stability, this project aims at broadening the industrial applications of magnesium aluminate to be used as grinding materials. Grinding materials are usually used in finishing the machining of metals parts to give it its final bright luster. This project is designed to increase the hardness of magnesium aluminate by incorporation of hard ceramic particulates such as borides or carbides. Titanium carbide (TiC) was chosen to be the reinforcement of magnesium aluminate matrix. This work targets at synthesizing MgAl2O4-TiC composite in a high dense form. The target composite will be synthesized by self-propagating high-temperature synthesis (SHS). SHS is an in-situ process that can perform synthesis and sintering in one step. To the best of our knowledge this composite in its dense form does not prepare by SHS. Different factors controlling the physical and mechanical properties of the final object will be investigated. This factors include, grain sizes of the starting materials, pressing load, initial temperature of the reaction, amount of ceramic and metallic additions.
Keynote Forum
Jun Yin
Georgia State University, USA
Keynote: Chemical tools to probe protein ubiquitination
Time : 00:00-00:30
Biography:
Jun Yin has completed his PhD from University of California, Berkeley and postdoctoral studies from Harvard Medical School. He is an Associate Professor at the Department of Chemistry of the Georgia State University. His research focus is ubiquitin-mediate cell signaling processes and the catalytic mechanisms of protein ubiquitination enzymes.
Abstract:
Ubiquitin (UB) is transferred through an E1-E2-E3 enzymatic cascade to the substrate proteins to regulate their stability and biological functions in the cell. The human genome encodes 2 E1s, 45 E2s, and more than 600 E3s. Together they assemble a complex network of UB transfer for the modification of cellular proteins. Currently, key questions are unsolved on how to identify ubiquitination targets of important E3s to map them on the cell signaling networks, and how UB chains of specific linkages are assembled to encode unique signals in the cell. We have developed a method that we refer to as “orthogonal UB transfer” (OUT) to untangle the complexity of protein ubiquitination networks. The key to OUT is to engineer a cascade of engineered E1, E2 and E3 enzymes (xE1, xE2, and xE3) that exclusively transfers an engineered UB (xUB) to the substrates of a xE3. We express xUB and the OUT cascade in the cell, purify xUB-conjugated proteins, and reveal their identities by proteomics. The proteins from the OUT screen are the potential substrates of the E3 in the OUT cascade. We have developed OUT cascades with HECT E3 E6AP and U-box E3s E4B and CHIP and identified new cellular circuits regulated by these E3s. To investigate the mechanism of E2-catalyzed UB chain synthesis, we have generated linkage-specific di-UB conjugates by unnatural amino acid incorporation and expressed protein ligation. The di-UB conjugates mimic the binding modes of donor and acceptor UBs at the E2 active site for UB chain synthesis. By characterizing the structure of E2-diUB conjugates, we are to reveal how E2 regulates the synthesis of UB chains of different linkages.
Keynote Forum
Xintao Wu
Fujian Institute of Research on the Structure of Matter, China
Keynote: Investigations of transition metal complexes with fluorescence or metal to metal charge transfer properties
Time : 00:00-00:30
Biography:
Professor Xin-Tao Wu graduated from Xiamen University in 1960 and completed his Master Degree in Science from Fuzhou University in 1966. He is Professor of Chemistry, Director of the Academic Committee from 2000 to 2013, Fujian Institute of Research on the Structure of Matter, Chinese academy of Sciences, and has been a Member of the Chinese Academy of Sciences from 1999. He has published more than 300 papers in reputed international chemical journals.
Abstract:
Metal-organic framework materials with fluorescent, white light or gas-adsorption properties, and transition metal clusters with metal to metal charge transfer properties have become of much interest in fundamental research and modern material science. Recently, the following investigations have been made in my res错误!è¶…é“¾æŽ¥å¼•ç”¨æ— æ•ˆã€‚earch group: (1) A series of neutral MOFs encapsulated various neutral and ionic guest dye molecules have been designed and synthesized, their luminescent properties have been investigated. The white light- emitting MOF materials could be designed and prepared when three red/green/ blue-emitting dyes were introduced simultaneously into such MOF host. Interestingly, the white light is tunable by changing the content or type of the three dye guests, or the excitation wavelength. (2) A series of new luminescent zinc or lanthanide phosphonates and their luminescent properties have been investigated. Furthermore, some lanthanide phosphonates exhibit the remarkable capability to rapidly detect trace amounts of nitroaromatic explosives through luminescent quenching. The sensitivity, fast response, facile synthesis, low usage, cheapness, and good stability make it one of the most powerful nitroaromatic explosives sensors known. (3) A series of mixed valent cyanidometal bridged compounds have been designed, synthesized and characterized, their metal to metal charge transfer properties and the influence factors of electron transfer process have been investigated. In particular, an unusually delocalized mixed-valence state of a cyanidometal bridged compound induced by thermal electron transfer have been reported for the first time.
Keynote Forum
Saad Alotaibi
Taif University, KSA
Keynote: Synthesis of magnesium aluminate composites reinforced with ceramic particulates for grinding applications
Time : 00:00-00:30
Biography:
Saad Alotaibi has completed his PhD at the age of 28 years from Western Michigan University and postdoctoral studies from King Abdullah University School of Chemistry. He is the Dean of Turabah University College. He has published more than 8 papers in reputed journals and has been serving as an editorial board member of repute
Abstract:
This project aimed at investigating the possibility to synthesize magnesium aluminate composite reinforced with ceramics particulates to be used as grinding materials. Generally, magnesium aluminate is commonly used in the industries as refractories. Due to its high chemical stability, this project aims at broadening the industrial applications of magnesium aluminate to be used as grinding materials. Grinding materials are usually used in finishing the machining of metals parts to give it its final bright luster. This project is designed to increase the hardness of magnesium aluminate by incorporation of hard ceramic particulates such as borides or carbides. Titanium carbide TiC was chosen to be the reinforcement of magnesium aluminate matrix. This work targets at synthesizing MgAl2O4-TiC composite in a high dense form.
The target composite will be synthesized by self-propagating high temperature synthesis SHS. SHS is an insitu process that can perform synthesis and sintering in one step. To the best of our knowledge this composite in its dense form does not prepare by SHS.
Different factors controlling the physical and mechanical properties of the final object will be investigated. This factors include, grain sizes of the starting materials, pressing load, initial temperature of the reaction, amount of ceramic and metallic additions.
Keywords: Magnesium aluminate – Titanium carbide- composites – synthesis - sintering
- Sessions & Tracks:
Analytical Chemistry
Physical Organic Chemistry
Inorganic and Bioinorganic Catalysis
Medicinal Chemistry, Drug Synthesis
Inorganic Materials and Nanoparticles
Organometallic Chemistry
Advanced Synthesis and Catalysis
Modern Organic Chemistry and Applications
Session Introduction
Mahesh Sanzgiri
St. Xaviers College, India
Title: Synthesis of azomethines of anthrones and 10- arylidene anthrones and testing for anticancer and anti-aids activity
Time : 00:00-00:25
Biography:
Dr Mahesh N. Sanzgiri MSc, PhD in organic chemistry from Bombay University in 1984 under guidance of Professor V. V. Nadkarny of St. Xavier’s College, Mumbai. His research is dedicated to “study of few derivatives of anthrone and pheromones. His research work for application of derivatives of anthrone in anti-cancer and antiaids activity is a new approach with synthesizing organic compounds using functional groups for trapping active cancer cells and removing aids activity. He is also working on isolation and synthesizing of Tiger pheromones from Tiger urine and preparing same molecule in lab synthetically by using chemical method. Its application is in Wild Perfumes. With wide experience in working with multinational German Chemical and Pharma Co. Merck in India for many years on responsible position, presently he works as a freelance scientist and consultant for doing research and development, also consultant for cGMP, WHO, USFDA, ISO etc. with various well-known Indian & multinational Indian and foreign companies.
Abstract:
A new series of azomethines of anthrones have been prepared by condensing anthrone with different primary amines, o-aminophenol, and p-aminobenzoic acid. Similarly, 10-Arylidene anthrones with different functional groups were synthesized using Acetic Anhydrite as well as ethanol as solvent. It is found that Azomethines of anthrones prepared by condensing primary amines with the nitro group in p-position of aromatic ring indicate intense anticancer activity in-situ as compared to other azomethines of anthrones. It is also proved that azomethine group stabilized by aromatic ring shows anticancer activity, but Nitro group in p-position of an aromatic ring can be considered for further investigation for the development of an anticancer drug, after doing detailed toxicity studies. Similarly, 10-Arylidene anthrones with Nitro group in p-position of the aromatic ring shows anti aids activity in-situ. However detailed studies of toxicity should be done before considering for further development of antiaids drugs.
Ali Mohd Lone
Govt. Degree College for Women Baramulla, India
Title: Divergent approaches to the synthesis of fused furo[3,2-b]furanone scaffold embodied in bioactive natural products
Time : 00:00-00:25
Biography:
Prof. A M Lone completed his Ph.D in Medicinal Chemistry from Indian Institute of Integrative Medicine (IIIM) Jammu and is currently working as Assistant Professor in the Department of Chemistry Govt Degree College for Women Baramulla. He has expertise in the total synthesis of bioactive molecules, development of novel strategies and structural modification of natural molecules for lead optimization.
Abstract:
Furo-furanones are the bicyclic compounds in which furan ring is attached to a furanone ring through face-b. Functionally embellished furo[3,2-b]furanone moiety has been widely encountered as a distinctive sub-structure among a diverse range of natural products of mixed biosynthetic origin (Figure). Representative examples of natural products incorporating the furo[3,2-b]furanone segment as part of their complex architecture are neovibsanins A and B), lactonamycin, schisandra nortriterpenoids (e.g., micrandilactone A), plumericin, pallavicinin and neopallavicinin and plakortones (e.g., plakortone E). All these natural products exhibit wide-ranging biological activities. Thus, the furo[3,2-b]furanone core appears to be a promising and potent pharmacophoric group that imparts considerable therapeutic value to the natural products that embody it. This attribute along with the complex, challenging and diverse natural product architecture into which furo[3,2-b]furanone core is embedded, has generated considerable interest in assembling this moiety. In the present study, a simple and straightforward methodology of general utility to construct sterically encumbered furo[3,2-b]furanone scaffolds present in a diverse range of bioactive natural products is delineated. The methodology emanates from readily available Morita–Baylis–Hillman (MBH) adducts and employs sequential ring closing metathesis and oxy-Michael addition cascade as the key steps.
Figure. SAR of 2-alkyl/aryl-aminomethylene cycloalkane-1,3-diones against M. Tuberculosis.
Tanvir Sultana
Bangladesh University of Engineering and Technology, Bangladesh
Title: Physicomechanical and thermal properties of betel nut husk nanofiber reinforced polymer composites
Time : 00:00-00:25
Biography:
Mrs Tanvir Sultana is a PhD student of Bangladesh University of Engineering and Technolog, BUET, Dhaka under the supervision of Professor Md. Wahab Khan. She has published 3 papers in the reputed journal. She is a PhD fellow of Bangladesh University Grant Commission (UGC). She is an Assistant Professor of Chemistry of the government college of Bangladesh under Ministry of Education.
Abstract:
Cellulose extracted from Betel Nut husk fiber were converted to cellulose nanofiber by chemical and mechanical technique to examine their potential for use as reinforcement fiber in biocomposite applications. The cellulose isolated from betel nut husk fiber were subjected to acid hydrolysis using 62% sulfuric acid under ultrasonic treatment. The product was allowed to stand at room temperature to cool and the acid was removed by washing, centrifuged and dialysis with distilled water at room temperature. Betel nut husk fiber was also converted to nanofiber by the milling process. The present work was to investigate the possibility of breaking down the structure to submicron and nanoparticles by high energy planetary ball milling by SFM-1 Desk-Top planetary Ball-Miller, MTI Corporation. Cellulose nanofiber reinforced polymer composites were prepared with different weight percentages (1 wt% to 5 wt%) via casting methods. The tensile, thermal and morphological properties were studied for all composites. Enhancement in the tensile, thermal and morphological properties was shown in the nano-cellulose reinforced composites. Cellulose nanofiber and its reinforced polymer composites were characterized by FTIR, TGA, DSC, Nano Zetasizer, and X-ray diffraction. Its structural morphology was also studied by Scanning electron microscope.
Kallol K. Ghosh
Pt. Ravishankar Shukla University, India
Title: Design and development of novel functionalized surfactants and mixed micellar systems for chemical reactions
Time : 00:00-00:25
Biography:
Dr Kallol Kumar Ghosh is currently a Professor of Chemistry in School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur, India. He received his MSc Degree ( Physical Chemistry) in 1981 and PhD Degree in 1986 from Pt. Ravishankar Shukla University under Professor S G Tandon. He has done postdoctoral work on artificial siderophores in the laboratory of Professor Akira Katho, Seikei University, Tokyo, Japan as an INSA JSPS visiting fellow. He was a James Chair visiting fellow in St. Francis Xavier University, Antigonish, Canada. He is the recipient of Bronze Medal of Chemical Research Society of India and Prof. B. N. Ghosh award of Indian Chemical Society. His research interest comprises surface chemistry, chemical kinetics and reaction mechanism, development of novel reactivators, micellar catalysis, micellar enzymology, functional surfactants, surfactant protein interactions, ionic liquids, and nanomaterials. He has published more than 170 research papers in various national and international journals. Under his supervision, 26 persons have completed Ph.D. Apart from his teaching and research activities, he has been engaged in various professional activities of Pt. Ravishankar Shukla University, to name a few, Director, National Centre for Natural Resources, Coordinator Public outreach center, and coordinator Inspire program etc.
Abstract:
The studies on kinetics and physicochemical properties of novel functionalized green surfactants are of paramount importance for the acyl transfer reactions. Over the past several years we have been trying to figure out new micellar hydrolytic catalysts as nonreactors for the various chemical reactions. The functionalized surfactants with pyridinium/ imidazolium core in their head groups and α-nucleophilic moiety viz. oximate/hydroxamate/ amidoximate groups have been established. More recently, however, the focus has shifted to surface active ionic liquids (SAIL) as a green micellar system. In this presentation, the important trends, recent development and novel strategies for the kinetic efficiency of some pyridinium based functionalized surfactants and SAIL toward the micellar hydrolysis of carboxylic and phosphate esters will be reviewed. The physicochemical and surface properties of a single and mixed system of functionalized surfactants have been studied by surface tension, conductivity and fluorescence measurements. The deprotonation behavior has also determined. The various quantitative kinetic models and theories of mixed micellization have also been applied successfully.
Senait Aklog
Bahir Dar Institute of Technology, Ethiopia
Title: Atomic absorption spectrometric determination of the concentration of Fe, Mn, Pb and Cd in fruits of mango, avocado and papaya from Gondar “Arada†Market Gondar, Ethiopia
Time : 00:00-00:25
Biography:
Ms. Senait Aklog Tesfaw, has full chemistry back ground in both BSc. and MSc. Currently, she is a lecturer in analytical chemistry and working at Bahir Dar University Institute of technology Ethiopia, based on her academic and work profession. Her main responsibilities are teaching, conducting research, giving community service, organizing laboratories, assisting project works on chemical engineering students, preparing modules and participating in different affairs of our institution. Recently she has one published paper and two research works which have been completed and is trying to publish those research works.
Abstract:
Statement of the Problem: Contaminations of the environment by heavy metals with their potential effect on health, agriculture and natural ecosystem have a subject of worldwide concern. In Ethiopia, especially in the place where some fruits are found such as Gondar and Bahir Dar, fruits have been used for human consumption without having knowledge of the content of essential and non-essential elements in some selected fruits.
Purpose of this study: It is to aware the society to be careful when they are eating not to take the fruit above and below their threshold limit or daily allowance limit because the fruits contain some heavy and toxic metals which have a great role in affecting human health.
Methods: An atomic absorption spectrometer has been used for the study. Additionally, Different wet-digestion methods were tested to select optimum procedure. The validity of the optimized digestion procedure for fruits was checked by carrying out spiking test and analyzing percent recovery. The study was analyzed using Origin 8 and SPSS (version 20) software.
Results: The mean concentrations of Fe, Pb, and Mn, in fruit were comparable with WHO recommended values but the concentration of Cd showed greater than the threshold value.
Conclusion: The results of sample analysis and their comparison with standard values showed that the average concentration of all heavy metals in the studied fruits was comparable with the standard levels of the WHO they had acceptable conditions for human consumption except the level of Cd.
Recommendations: It would be worthwhile doing a comprehensive analysis not only fruits but also vegetable, soil, and water at different farm places.
Table1. Comparison of Mean concentrations of trace metals of mango sample with recommended (WHO/FAO) values and other publications
Where E = element , TSAC = This study avergae concentration
|
E |
TSAC(µg/g)
|
(Mahdavian, et al.,2008) |
(Zahir et al .,2009) |
Permissible value (µg/g)
|
|
Mango |
||||
|
Fe |
65.5 ±1.2 |
75.16 |
9.5 ± 4.3 |
75 |
|
Pb |
0.25 ± 0.1 |
67.20 |
1.9 ± 0.9 |
0.3 |
|
Cd |
0.2 ± 0.02 |
16.9 |
0.27 ± 0.05 |
0.1 |
|
Mn |
3.9 ± 0.09 |
11.59 |
0.05 ± 0.03 |
5 |
Davoud Dastan
Georgia Institute of Technology, USA
Title: Development in organic field effect transistors based on organic-inorganic materials
Biography:
Dr Davoud Dastan is a research associate at Georgia Institute of Technology. Prior to his appointment at George Tech., he was a post-doc. fellow at Cornell University, Ithaca, New York, USA. He is working on nanomaterials for energy applications. He has published several papers and has been serving as an editorial board member of repute.
Abstract:
Nanocomposite materials have been used to fabricate organic field-effect transistors (OFET’s) using low-cost spin coating technique. The composite materials demonstrated outstanding properties such as high dielectric constant and high homogeneity. These devices are common in modern day development of organic electronics. Until recently, most research regarding OFET’s has been focused on developing novel process techniques whereas enhancement in the mobility has remained stagnant. Gold contacts were thermally made on top of the substrates to fabricate top-contact bottom-gate devices. High dielectric constant (k) materials were employed to decrease the power consumption of the fabricated FET’s. The current leakage was very low which indicates the reliability of these devices based on high-k materials. The electrical features such as output and transfer characteristics of the devices were measured using semiconductor parameter analyzer. The obtained results illustrated low operating voltage, high ON current and fast operation. Additionally, the simulation was performed to elucidate the growth mechanism of gate layer on the substrates and its contribution to the enhancement of the electrical properties of the fabricated devices.
- Posters & e-posters:
Session Introduction
Mohammad H. Alotaibi
King Abdulaziz City for Science and Technology, Kingdom of Saudi Arabia
Title: Hydrogen generation from formic acid decomposition using a Iradium-Palladium (Ir-Pd) nanoparticles supported on different supports
Time : 00:00
Biography:
Abstract:
Introduction: In recent years, attention was turned to hydrogen generation and their importance rule in future energy and for storage/generation for fuel-cells-based H2. Formic acid (HCOOH) is the main product from biomass processing has important possess such as handled safely in aqueous solution, high-energy density, non-toxic material, high energy density and excellent stability at room temperature. Two expected pathways for the decompositions of formic acid, dehydrogenation to produce hydrogen (H2) and carbon dioxide (CO2) which shows in equation 1, and dehydrogenation to produce carbon monoxide (CO) with water (equation 2).
HCOOH (l) H2 (g) + CO2 (g) ∆G298K= - 35.0 kJmol -1 (Equation 1)
HCOOH (l) H2O (l) + CO (g) ∆G298K= - 14.9 kJmol -1 (Equation 2)
Production of CO can poison the catalyst. Therefore, it is important to find catalyst can push the reaction selectively to follow the first pathway.
Experimental/methodology: (0.5, 1 and 2 % mole) of Ir using iridium chloride obtain from (Sigma-Aldrich) were mixed with 15% Hydrochloric acid in a flask under stirring and heating at 80 °C, and 3 g active carbon or TiO2 obtained from (Alpha Chemical) was then added. The mixtures were continuously stirred and heated at 80 °C overnight, then washed with distilled water several times and dried at 100 °C overnight. Then, the final catalysts were calcined and reduced at 400 °C for 4 h. Furthermore, (2.5 % mole ratio) of Ir using iridium chloride obtain from (Sigma-Aldrich) and Pd (0.5, 1 and 2 % mole ratio) using Pd acetate obtained from (Sigma-Aldrich) were mixed with 15% Hydrochloric acid in a flask under stirring and heating at 80 °C, and 3 g active carbon or TiO2 obtained from (Alpha Chemical) was then added. The mixtures were continuously stirred and heated at 80 °C overnight, then washed with distilled water Several times and dried at 100 °C overnight. Then, the final catalysts were calcined and reduced at 400 °C for 4 h.
Results and discussion: In this investigation, we aim to study the effect of Iridium and Palladium noble metals supported on two different supports for the decompositions of formic acid. Several catalysts of supported Iridium and Palladium with different metal ratio have been prepared by impregnation method. The physicochemical properties of the prepared catalysts were characterized with XRD, TEM, EDS, IR, UV, and BET. These catalysts were tested for the decompositions of formic acid using liquid phase reaction. The reaction conditions were decomposition of 10 ml of diluted formic acid (0.5 M, 0,005 mol) on the known amount of the catalyst with ratio 1:1000. The reaction temperature was varied and that for 4 hours reaction time. In conclusion, Ir and Pd bimetallic show very strong interaction and exhibited a good stability and high activity for the decomposition of formic acid to produce hydrogen.
Muluye Melak Zenebe
University of Gondar, Ethiopia
Title: Isolation, structural elucidation, and bioactivity studies of leaf extract of Vernonia amygdalina
Time : 00:00
Biography:
Abstract:
Vernonia amygdalina (VA) is a tropical African plant of the Asteraceae family and is occasionally cultivated for its medicinal uses, which include as a treatment for diarrhea, skin wounds, fever mastitis and warms infection. The aim of this study is to isolate and elucidate the structure of some of the chemical constituents from the leaf of Vernonia amygdalina and its bioactivities. Methanol extract of Vernonia amygdalina, after repeated chromatography led to the isolation of a different compound, one of this compound (MM-4) is partially characterized based on the spectral data (IR, 1H NMR, 13C NMR, and DEPT) and Extracts from Vernonia amygdalina have been shown to have antimicrobial activity.
Key words: - Vernonia amygdalina, Asteraceae
Seok-Young Oh
University of Ulsan, South Korea
Title: Sorption of nitro explosives to polymer/biomass-derived biochar: Affecting factors and toxicity
Time : 00:00
Biography:
Abstract:
Factors affecting the sorptive removal of nitro explosives [2,4,6-trinitrotoluene (TNT) and hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)] to polymer/biomass-derived biochar were investigated through batch experiments. Compared to that of rice straw (RS)-derived biochar, the sorption of TNT and RDX to polymer/RS-derived biochar was greatly enhanced by more than 2.5 and 4 times, respectively. The type and amount of polymer did not significantly affect the sorption of nitro explosives to polymer/RS-derived biochar. Due to increasing aromaticity of biochar and decreasing carbon residues from the polymer, the effect of the pyrolysis temperature at elevated temperatures was not marked. Surface treatment with acid or an oxidant did not significantly change the sorption capacity, suggesting that polymer residues may be strongly responsible for the enhancement. Possible polymer residues were identified via GC-MS analysis. The toxicity characteristic leaching procedure (TCLP) and Microtox bioassay analyses indicated that polymer/RS-derived biochar did not show possible harmful effects. Our results suggest that polymer/RS-derived biochar can be effectively used as a sorbent to remove nitro explosives both in the natural environment and engineered systems.
Huan Pang
Brown University, Providence, USA
Title: Comparative study of solid state and solution aldol reaction of lithium enolate of pinacolone
Time : 00:00
Biography:
Abstract:
We reported the first systematic study of the solid-state aldol reactions of lithium pinacolone enolate with various aromatic solid aldehydes, in comparison with the same reactions performed in tetrahydrofuran (THF) solution. In solution, the reactions are selective with the aldol condensation product, except for the reaction involving 2-nitrobenzaldehyde. In the solid state, the reactions with THF-solvated lithium enolate of pinacolone showed the mixture of aldol condensation and aldol addition products. The usage of unsolvated lithium enolate of pinacolone in the solid state reactions resulted in a higher ratio of aldol addition to aldol condensation product than THF-solvated lithium enolate of pinacolone. At lower temperatures (0 °C), the solid state reactions can afford a higher ratio of aldol addition to aldol condensation product in the system. The solid-state reactions generally afforded low yields and low conversion of the aldehydes. For those aldehydes with halogen group on the para position of benzaldehyde, the Tishchenko product was formed in a large amount in the system catalyzed by lithium enolate of pinacolone (as the strong base).
Marise Garcia Batlle
National Autonumous University of Mexico, Mexico
Title: Synthesis of radiolabeled aromatic bisphosphonates and their potential application in bone metastasis pain palliation.
Time : 00:00
Biography:
Abstract:
Introduction: Bone metastases are the most frequent complication in the 80% of patients in advanced oncological stages. They are usually incurable, produce severe pain, decreasing the expectancy and quality of life of patients. Bisphosphonates are the main compounds employed for that purpose; nevertheless, their synthesis is relatively a complex process. The aim of the present work was to develop a simple synthesis method of aromatic bisphosphonates, potentially useful to alleviate metastatic bone pain, from their respective amino acids.
Materials and Methods: L-phenylalanine was used as starting material. The synthesis had three stages: 1) Protection of the amino group with a 1: 1 mixture of formic acid (98%) and acetic anhydride; 2) phosphonation of the protected phenylalanine with a mixture of H3PO3 and PCl5; 3) hydrolysis. The sodium salt of the 2-amino-3-phenyl-1-hydroxypropyl-1,1-bisphosphonic acid and the iodinated derivative thereof was obtained. The compounds obtained were characterized by infrared spectroscopy, 1H-NMR, 13C-NMR. The iodogen method was used for the labeling of the sodium salt obtained with 125I.
Results: The yield of the protection reaction of the amino group ranged between 75 and 80% and that of the phosphonation between 50 and 60%. All the compounds were obtained with a suitable purity evaluated by spectroscopic techniques.
Conclusions: A synthesis method was developed with novel modifications that allowed to obtain, both the sodium salt of the 2-amino-3-phenyl-1-hydroxypropyl-1,1-bisphosphonic acid, as well as the iodinated derivative thereof from the L -phenylalanine.
Ganesh N Y
Govt. Science College, Visvesvarayya Technological University, India
Title: Green Synthesis of Pyrazolo-Pyrimidines by using Ionic Liquids as potent EAC receptor antagonists.
Time : 00:00
Biography:
Abstract:
Pyrazolo-Pyrimidines are Heterocycles having nitrogen based hetero atom which is the main composition to exhibit pharmacological efficacy. Since they resemble purine, have a great role in the field of medicinal chemistry. After thorough literature survey, we planned to synthesize the new compounds of Pyrazolo-Pyrimidines by different synthetic methodology followed the green chemistry approach. Here we reported one pot syntheses of Pyrazolo-Pyrimidines by using Ionic liquids & studied comparative with Nano-catalysts (Not named here). We found the Ionic liquids that used, are better for the synthesis by affording more yield & higher quality than nano-catalysts. The synthesized compounds were confirmed by 1HNMR, IR & C13NMR spectra. The compounds were tested for in-vitro anticancer activity against Ehrlich Ascites Carcinoma (EAC) cell line. Most compounds revealed significant anticancer activity relative to doxorubicin as positive control with IC50 values.
Huan Pang
Brown University, Providence, USA
Title: Comparative study of solid state and solution aldol reaction of lithium enolate of pinacolone
Biography:
Abstract:
We reported the first systematic study of the solid-state aldol reactions of lithium pinacolone enolate with various aromatic solid aldehydes, in comparison with the same reactions performed in tetrahydrofuran (THF) solution. In solution, the reactions are selective with the aldol condensation product, except for the reaction involving 2-nitrobenzaldehyde. In the solid state, the reactions with THF-solvated lithium enolate of pinacolone showed the mixture of aldol condensation and aldol addition products. The usage of unsolvated lithium enolate of pinacolone in the solid state reactions resulted in a higher ratio of aldol addition to aldol condensation product than THF-solvated lithium enolate of pinacolone. At lower temperatures (0 °C), the solid state reactions can afford a higher ratio of aldol addition to aldol condensation product in the system. The solid-state reactions generally afforded low yields and low conversion of the aldehydes. For those aldehydes with halogen group on the para position of benzaldehyde, the Tishchenko product was formed in a large amount in the system catalyzed by lithium enolate of pinacolone (as the strong base).