International Conference on Organic Chemistry August 10-11, 2016 Las Vegas, Nevada, USA

Imad A Abu-Yousef earned his PhD in Organo-Sulfur Chemistry in 1995 from McGill University (Montreal, Canada). Subsequently, he pursued a Post-doctoral fellowship in Polymer Chemistry at McGill University. His research work was recognized by prestigious institutions that have bestowed awards on him, including the Jordan Higher Education Natural Sciences Award (Jordan, 2010), the National Bank of Sharjah Excellence in Research and Scholarship Award (United Arab Emirates, 2002), and Abdul Hameed Shoman Award for Outstanding Young Chemist Researcher in the Middle East (Jordan, 2000). He has published more than 50 papers in reputed international journals and has been serving as an Editorial Board Member of the Journal of Saudi Chemical Society, an Elsevier Published Journal.

Fungicidal chemicals in crude form have been in use for several decades worldwide. This study aims at evaluating the anti-fungal activity of several novel chiral Schiff bases 3 and their reduction products 4, which were derived from various salicylaldehydes 1 and naturally occurring amino acid L-valine 2, against plant and food pathogens. The anti-fungal activity was assessed in vitro using the Poisoned Food Technique. The studied Schiff base derivatives exerted potent anti-fungal activity even at 25 ppm concentration. Some Schiff base derivatives caused 100% inhibition of Rhizoctonia solani and Colletotrichum capsici, two plant fungal pathogens at 1000 ppm concentration. Even at 100 ppm concentration, many Schiff base derivatives caused potent % inhibition of four common plant fungal pathogens (Rhizoctonia solani, Colletotrichum capsici, Phyllosticta sp., and Curvularia lunata). Indeed, Schiff bases and their reduction products displayed differential anti-fungal activities. The minimum inhibitory concentration (MIC) values of the examined Schiff bases and their reduction products against the respective fungal pathogens were also determined. Our study also reveals that the studied Schiff bases and their reduction products display fungicidal efficacy against common food fungal pathogens including Rhizopus sp., Fusarium sp., Penicillium sp., and Botrytis cinerea at 50-100 ppm concentrations. Collectively, our study demonstrates that the studied Schiff bases and their reduction products possess fungicidal properties against several plant and food fungal pathogens at concentrations as low as 25-50 ppm, suggesting that such compounds can serve as broad-spectrum fungicidal agents for the control of common phytopathogenic fungi.

Makoto Hashimoto has completed his PhD from Graduate School of Phamaceutical Science, Hokkaido University in Japan and Post-doctoral studies from Toyama University in Japan and Bath University. He joined Graduate School of Agriculture, Hokkaido University from 2011.

Photoaffinity labeling is a valuable chemical method for studying the interactions of biologically active molecules with their target molecules. In photoaffinity labeling, a covalent bond is formed between ligand and target proteins upon irradiation with UV light. For instance, to study biologically active peptide interactions for a target protein, a photoreactive aromatic -amino acid will be powerful probe for photoaffinity labeling. Photoreactive phenylalanine derivatives has been used for this purpose, but the construction of these compounds are base on condensation of photophore and -amino acid equivalents. Especially, trifluoromethylphenyl diazirine and benzophenone, which are very common photophores for photoaffinity labeling, are also of same status. We encouraged direct constructions of photophores on optically pure -amino acids as photoreactive phenylalanine derivatives. Tryptophan sometimes plays important role for biological activities. But the high reactivities of indole skelton on tryptophan hampered to synthesis of photoreactive tryptophan derivetives for photoaffinity labeling. Careful reaction setting to constructions of trifluoromethyldiazirine on indole promoted us to synthesize tryptophane metabolites comprehensively.

Hamad Al-Matar is Assistant Professor in Organic Chemistry at Kuwait University, Kuwait. In the year 2001, he completed PhD in Organic Chemistry from University of Sussex, Brighton, UK. In the year 1997, he completed his MSc in Organic Chemistry from Howard University, Washington DC, USA.

The reaction of active methylenes (cyclic and acyclic), phenols, 2-thiazolylacetonitrile and alkyl pyridazinyl carbonitriles with benzylidine malononitrile in ethanolic chitosan afforded amino pyrancarbonitriles 2, benzopyrancarbonitriles 3, thiazolopyridine 4, and benzopyridazines 5 respectively, in yields comparable to those obtained in ethanolic piperidine [1-3]. Much lower yields were obtained in aqueous solutions.

Xu Jing has completed his PhD from Dalian University of Technology. He is an associate professor in college of chemistry and environmental science of Hebei University.

Metal-organic frameworks (MOFs) and Metal-organic polyhedra systems that constructed through the coordination of metal ions and organic linkers, represent a unique class of functional molecular containers that display interesting recognition properties and fascinating reactivity reminiscent of the natural enzymes. These architectures generating welldefined cavities provided specific inner environments for selective bonding of guest molecules and catalyzing their reactions. The great flexibility in terms of the molecular design and the potential benefits of integrating inorganic and organic components within a single composite make them interesting candidates for supramolecular catalytic chemical transformation. Yet only few "artificial enzymes" achieved the magnificent catalysis of natural enzymes. Most metal-organic cages don't constitute specific interactions capable of encapsulating guest molecules and catalyzing the reactions, due to the intrinsic difficulties on the producing guest-accessible sites inside the well-define spaces. Through incorporating amide-containing multidentate chelators within the ligand backbone, herein we reported the synthesis and catalytic properties of several metal- organic hosts to investigate the possibility in the application of molecular sensing and molecular flasks for enzymatic catalysis.

Ali Morsali completed his High School Diploma in the year 1991 in Experimental Sciences, from Hakim Hidaji High School, Hidaj, Zanjan, Iran. He completed BSc (during 1992-1995), in Pure Chemistry from Tarbiat Moallem University, Tehran, Iran and MSc in Inorganic Chemistry (during 1996-1998) from Zanjan University, Zanjan, Iran. He obtained his PhD in Inorganic Chemistry (during 1999-2003) from Tarbiat Modares University (TMU), Tehran, Iran.

Two typical highly porous metal-organic framework (MOF) materials based on lead(II), [Pb(4-bpdh)(NO3)2(H2O)]n (TMU-1) and [Pb(4-bpdh)(NO3)2]n (TMU-2) have been used for the removal of harmful dyes (anionic dye methyl orange (MO) and cationic dye methylene blue (MB)) from contaminated water via adsorption. The adsorption capacities of TMU- 1 and TMU-2 are much higher than those of an activated carbon. Our results show that the difference between MO and MB adsorption in TMU-1 and TMU-2 could be related to pore size and coordinated H2O interactions. Dye elimination has also been studied by the use of adsorption/desorption process. The delivery of dyes from compounds in methanol at room temperature was determined by UV/Vis spectroscopy.

She is Research Associate from the year 2009 till present at Wroclaw University of Technology, Faculty of Chemistry at Wrocław Area, Poland Her specialization in organic chemistry and technology, chemistry of natural products (Open)2 honors and awards in The development of educational and scientific potential of the young academic staff of Wroclaw University of TechnologyThe development of educational and scientific potential of the young academic staff of Wroclaw University of Technology She was Research Associate at Poznan University of Technology from September 2001 – till May 2008 at Poznań Area, Poland.

Academic research on ionic liquids, across many varied applications, is strong and still growing area of interest. New chiral imidazolium-based ionic liquids containing (1R,2S,5R)-(–)-menthol substituent, having symmetrical structure of the salts, have been synthesized and characterized. Monocyclic terpen alcohol: (1R,2S,5R)-(–)-menthol, obtained from a variety of mint (Menthae L.), was used as a substrate in two different reactions to obtain 1,3-bis[(1R,2S,5R)-(–)-menthoxymethyl]imidazolium chloride [1], which is a prototype of chiral ionic liquids. After that, metathesis of this symmetrical imidazolium chloride with various organic and inorganic salts in menthol or water/menthol solution was carried out. The ion exchange reaction goes smoothly, with the satisfactory exceed (from 94 to 99%). Discussed symmetrical salts belong to Chiral Ionic Liquids (CILs) where the chirality resides in the cation and is associated with the presence of optical active (1R,2S,5R)-(–)-menthol. Obtained symmetrical salts are hydrophobic, and air- and moisture-stable under ambient conditions. Moreover, they are non-volatile and non-flammable. Some of the 1,3-bis[(1R,2S,5R)-(–)-menthoxymethyl]imidazolium salts [i.e.: chloride, bis(trifluoromethanesulfonyl) imide, acesulfame, saccharinate] possess excellent antielectrostatic properties and their ability to drain the surface charge is similar to these of a known antistatic agent (Catanac 609: American Cyanamin Co.). This research was financed by the National Science Centre (Poland) grant no. 2013/09/D/ST5/03904.

Marina Galdino da Rocha Pitta has completed her Doctorate degree and is currently, pursuing her Post-doctoral from Federal University of Pernambuco. During her Post-doctorate, she was an exchange student at Haute école d'ingénierie et d'architecture Fribourg, HES SO, Switzerland and completed a specialization in Pharmaceutical Engineering at Well E&C, South Korea. She has published more than 12 papers in reputed journals.

Cancer is considered as one of the most challenging diseases to treat because despite advancements in our understanding of the disease, several types still have no cure and some tumour cells have become resistant to the drugs currently available in clinics. Acridine and their derivatives represent a very interesting class of molecules due to their broad spectrum of activity, being used as chemotherapeutic agents against bacteria, protozoa, malaria, HIV and cancer. The present work describes the synthesis and the cell antiproliferation activity of compounds 3-Acridin-9-ylmethyl-5-acridin-9-ylmethylene-thiazolidine- 2,4-dione (LPSF - AA2) and 3-Acridin-9-ylmethyl-5-(4-methyl-benzylidene)-thiazolidine-2,4-dione (LPSF - AA4) which are derived from acridine-thiazolidinediones nucleus. The two synthetized thiazacridines were synthetized through three reaction steps: n-alkylation, Knoevenagel condensation followed by a Michael addition reaction. The structures of all the compounds were established by their spectroscopic and spectrometric data such as 1H NMR, IR and LC-MS. The compounds LPSF - AA2 and LPSF - AA4 were evaluated in vitro as potent anticancer agents in Raji, Jukart, T47D and NG97 cancer cell lines. These cells were subjected to anti-proliferative and apoptosis assays to elucidate the mechanism of cytotoxicity. The compound LPSF - AA2 showed high cytotoxicity (IC50 7.64±3.50 μM) on Burkitt´s lymphoma cells whereas LPSF - AA4 exhibited antiproliferative activity against the acute T cell leukemia with IC50 value of 30.14±0.65 μM. It was also observed that both thiazacridine derivatives were non-toxic against non-tumor cells compared to amsacrine drug. Interestingly, LPSF - AA2 didn’t induced apoptosis of Raji cells but led them to cell cycle arrest

Ya-Jun Hou has received her BS in Applied Chemistry from Sun Yat-sen University, China in the year 2014, and is currently pursuing her PhD in Physical Chemistry from Sun Yat-Sen University. Her research interests are supramolecular coordination assembly and its application.

Recently, our group has reported an octahedral Pd(II)-Ru(II) heteronuclear Metal-Organic Cage (MOC) compound whose host-guest chemistry and chirality has been thoroughly studied. In this work, we introduced Fe(II) to the construction instead of Ru(II) and thus obtained a MOC with same structure proved by X-ray single crystal diffraction through stepwise self-assembly of diimine ligand, naked Fe(II) and Pd(II) in mild conditions. The assembly process, affinity with phenylacetylene derivatives, electrochemistry as well as photochemistry properties were carefully investigated by NMR technique, CV test, UVVis and FL spectra, respectively. It was observed that, the Pd(II)-Fe(II) MOC showed good performance for degradation of DMSO to CH4 using TEOA as sacrificial agent under visible-light irradiation, with TON up to 285 in 6 h.

Kai Wu has received his BS in Chemistry from Lanzhou University, China in the year 2013. Currently, he is pursuing his PhD degree from Sun Yat-Sen University. His current research interests are centered on supramolecular coordination assembly and its application.

In supramolecular coordination chemistry field, coordination driven assembly of Metal-Organic Cages (MOCs) with welldefined shapes and unique cavities has drawn great attention in the past decades. A wide variety of applications, such as altering chemical reactivity, intriguing host-guest properties and potentials in chiral recognition, catalysis, as well as drug delivery and release have been thoroughly explored. In the present study, we have reported the host-guest and photochemistry study of ferrocene derivative guests, employing our MOC-16 as a host. The host-guest interaction of three ferrocene (Fc) derivative guests with MOC-16 host were thoroughly studied by NMR spectra, their optical property by UV-vis, FL spectra and their electrochemical behavior by CV was also studied. Surprisingly, the fluorescence of MOC-16 quenched rapidly when the ferrocene derivative guests were encapsulated by MOC-16 in water. Hence, it was observed that the fluorescence can be recovered simply by extracting guests from the cage cavity with organic solvent.