Hiroaki Sasai
Osaka University, Japan
Title: Construction of highly functionalized compounds via metal free transformations
Biography
Biography: Hiroaki Sasai
Abstract
Highly efficient [n+2] type annulations have been realized utilizing chiral organocatalysis. Densely functionalized optically active heterocycles having tetrasubstituted carbon stereogenic center were synthesized from allenoate derivatives with either ketimine derivatives or symmetrical dienones. Among the organocatalysts we examined, ï¢-ICD1 showed high enantioselectivity for [2+2] annulation2 and (R)-SITCP3 was effective to [4+2]4 and [3+2]5 annulations.