MarÃa Del RocÃo Gámez Montaño
Universidad de Guanajuato, Mexico
Title: Synthesis of novel tetrazol-chromones via Ugi-azide reaction and in vitro studies for their antibiotic properties
Biography
Biography: MarÃa Del RocÃo Gámez Montaño
Abstract
As a part of our ongoing program to develop short and versatile Ugi-azide based methods toward poly-heterocycles containing the 1,5-disubstituted tetrazole moiety, here I show my resent results about in vitro studies of eighteen newly synthesized tetrazol-chromones against series of pathogenic parasites (Entamoeba histolytica, Giardia lamblia, and Trochomonas vaginalis), pathogenic bacteria (Pseudomonas aeruginosa, and Staphylococcus aureus), and human fungal pathogens (Sporothrixschenckii, Candida albicans, and Candida tropicalis). Moderate to good values were found in all cases, however, the best activity was observed in iodine-containing analogues against G. lamblia and C. albicans. These results have been published recently