Tuanli Yao
Shaanxi University of Science and Technology, China
Title: Title: Synthesis of 9,10-phenanthrenes via palladium-catalyzed aryne annulation by o-halostyrenes and formal synthesis of (±)-tylophorine
Biography
Biography: Tuanli Yao
Abstract
Phenanthrenes are valuable skeletons found in numerous biologically active natural products and medicinal compounds. They are also a common structural motif in material science because of their unique photochemical and electroluminescent properties. A novel palladium-catalyzed annulation reaction of in situ generated arynes and o-halostyrenes has been developed, which affords moderate to excellent yields of substituted phenanthrenes and tolerate a variety of functional groups such as nitrile, ester, amide, and ketone. This annulation chemistry has been successfully applied to the formal total synthesis of a biologically active alkaloid (±)-tylophorine.