Narayan S Hosmane
Northern Illinois University, USA
Title: Dendritic and nanostructured boron and carbon compounds for cancer therapy
Biography
Biography: Narayan S Hosmane
Abstract
In recent years, many efforts have been devoted to developing nanomaterials-based boron drugs for neutron capture therapy (NCT) and to date, a majority of the studies have proved reasonably promising. Conversely, further in vivo studies and clinical trials are needed to establish them as appropriate boron carriers; this is especially so with the relatively novel boron and carbon nanotubes and magnetic nanoparticles. More advanced forms of boron nanotubes can be anticipated as much interest in their synthesis as their future applications. Thus, boron neutron capture therapy (BNCT) is a promising treatment for malignant brain tumors as well as for other types of cancers, such as, liver, prostate, bladder, breasts, head and neck tumors. Current research focuses on both the design and synthesis of high boron containing compounds as BNCT agents, and the search for suitable delivery vehicles. To be suitable BNCT agents, the problem of their low water-solubility needs to be resolved by chemical modification. In the case of magnetic nanoparticles, strategies are required to counter their tendency of embolization and their unclear cytotoxicity must be resolved.
(a) 
(b)
Synthesis and biodistribution of carborane-appended magnetic nanocomposites without (a) and with (b) external magnet (1.14 Tesla).