Beena Jose
Vimala College, India
Title: Isolation and characterization of phytoconstituents and evaluation of anticancer potential of the medicinal plant Wrightia tinctoria (Roxb.) R. Br. from South India
Biography
Biography: Beena Jose
Abstract
Wrightia tinctoria R. Br. belongs to family Apocynaceae commonly called as “Jaundice curative tree” in South India. In Siddha system of medicine, it is used for psoriasis and other skin diseases. In the present study various secondary metabolites from the leaf and bark of Wrightia tinctoria (Pala Indigo) were isolated by column chromatography and characterized by spectral analysis (1H NMR, 13C NMR, IR, Mass Spectrum). The antibacterial and antifungal activities of the plant extracts against various pathogenic bacteria such as Bacillus cereus, Enterobacter faecalis, Salmonella paratyphi, Staphylococcus aureus, Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae, Pseudomonas aeruginosa and Serratia marcescens and antifungal activity against two fungi namely Aspergillus niger and Penicillium chrysogenum were evaluated by ‘agar well diffusion method'. The anticancer potential of Wrightia tinctoria was studied both in vitro and in vivo. Anti-tumor properties of Wrightia tinctoria could be linked with the presence of antioxidants and cytotoxic activity. These outcomes indicate the possible potential use of Wrightia tinctoria as anti-tumor agent.