Ganesh N Y
Govt. Science College, Visvesvarayya Technological University, India
Title: Green Synthesis of Pyrazolo-Pyrimidines by using Ionic Liquids as potent EAC receptor antagonists.
Biography
Biography: Ganesh N Y
Abstract
Pyrazolo-Pyrimidines are Heterocycles having nitrogen based hetero atom which is the main composition to exhibit pharmacological efficacy. Since they resemble purine, have a great role in the field of medicinal chemistry. After thorough literature survey, we planned to synthesize the new compounds of Pyrazolo-Pyrimidines by different synthetic methodology followed the green chemistry approach. Here we reported one pot syntheses of Pyrazolo-Pyrimidines by using Ionic liquids & studied comparative with Nano-catalysts (Not named here). We found the Ionic liquids that used, are better for the synthesis by affording more yield & higher quality than nano-catalysts. The synthesized compounds were confirmed by 1HNMR, IR & C13NMR spectra. The compounds were tested for in-vitro anticancer activity against Ehrlich Ascites Carcinoma (EAC) cell line. Most compounds revealed significant anticancer activity relative to doxorubicin as positive control with IC50 values.