Mahesh Sanzgiri
St. Xaviers College, India
Title: Synthesis of azomethines of anthrones and 10- arylidene anthrones and testing for anticancer and anti-aids activity
Biography
Biography: Mahesh Sanzgiri
Abstract
A new series of azomethines of anthrones have been prepared by condensing anthrone with different primary amines, o-aminophenol, and p-aminobenzoic acid. Similarly, 10-Arylidene anthrones with different functional groups were synthesized using Acetic Anhydrite as well as ethanol as solvent. It is found that Azomethines of anthrones prepared by condensing primary amines with the nitro group in p-position of aromatic ring indicate intense anticancer activity in-situ as compared to other azomethines of anthrones. It is also proved that azomethine group stabilized by aromatic ring shows anticancer activity, but Nitro group in p-position of an aromatic ring can be considered for further investigation for the development of an anticancer drug, after doing detailed toxicity studies. Similarly, 10-Arylidene anthrones with Nitro group in p-position of the aromatic ring shows anti aids activity in-situ. However detailed studies of toxicity should be done before considering for further development of antiaids drugs.